Zotsatira za kafukufukuyu zinasonyeza kuti amuna omwe analandira jekeseni wa testosterone undecanoate wautali anali wotsatira kwambiri chithandizo pambuyo pa chaka cha 1 kuposa amuna omwe analandira jekeseni wa testosterone propionate waufupi.
Kufufuza kobwerezabwereza kwa deta kuchokera kwa amuna oposa 122,000 ku United States kunasonyeza kuti amuna omwe amachiritsidwa ndi testosterone undecanoate (Aveed, Endo Pharmaceuticals) anali ndi chiwerengero chofanana chotsatira m'miyezi yoyamba ya 6 ya chithandizo monga amuna omwe amachitira ndi testosterone cypionate.Miyezo yotsatiridwa imachokera ku 7 mpaka miyezi ya 12, ndi 8.2% yokha ya odwala omwe amachiritsidwa ndi testosterone cypionate akupitiriza kulandira chithandizo kwa miyezi 12 poyerekeza ndi 41.9% ya odwala omwe amathandizidwa ndi testosterone undecanoate.
"Umboni umasonyeza kuti mitundu yabwino kwambiri ya mankhwala a testosterone, monga jekeseni wokhalitsa, ndi wofunikira kuti amuna omwe ali ndi vuto la testosterone apitirize kulandira chithandizo," anatero Abraham Morgenthaler, MD, pulofesa wothandizira opaleshoni.Helio adati amagwira ntchito mu dipatimenti ya urology ku Beth Israel Deaconess Medical Center ku Harvard Medical School."Pali kukula kuzindikira kuti kusowa kwa testosterone ndi vuto lofunika la thanzi komanso kuti mankhwala a testosterone amatha kusintha osati zizindikiro zokha komanso ubwino wa thanzi monga kuwongolera shuga m'magazi, kuchepa kwa mafuta ndi kuwonjezeka kwa minofu, kusinthasintha, kuchulukira kwa mafupa ndi chifukwa chosadziwika bwino. .kuchepa kwa magazi m'thupi.Komabe, ubwino umenewu ungapezeke ngati amuna amatsatirabe chithandizo.”
Morgenthaler ndi anzake adachita kafukufuku wamagulu a kafukufuku wa deta kuchokera ku database ya Verdigm, yomwe ili ndi deta yamagetsi yamagetsi kuchokera ku malo osungirako odwala ku US, kuphatikizapo omwe anayamba jekeseni testosterone undecanoate kapena testosterone cypionate pakati pa 2014 ndi 2018. Amuna a zaka za 18 ndi kupitirira.Deta yomwe yasonkhanitsidwa mu increments ya mwezi wa 6 kuyambira July 2019. Thandizo lothandizira limatanthauzidwa ngati nthawi pakati pa nthawi yosankhidwa yomwe siinapitirire kawiri nthawi yovomerezeka ya masabata a 20 kwa testosterone undecanoate kapena masabata a 4 a testosterone cypionate.Kutsatiridwa ndi chithandizo kunayesedwa kuyambira tsiku la jekeseni yoyamba mpaka tsiku losiya, kusintha kwa mankhwala, kapena kutha kwa mankhwala a testosterone omwe adalembedwa poyamba.Kusagwirizana kwa Testosterone mu gulu la testosterone undecanoate kunatanthauzidwa ngati kusiyana kwa masiku oposa 42 pakati pa tsiku lomaliza la kusankhidwa koyamba ndi tsiku loyamba la kusankhidwa kwachiwiri, kapena kusiyana kwa masiku oposa 105 pakati pa kusankhidwa kwamtsogolo.Kusatsatira gulu la testosterone cypionate kunatanthauzidwa ngati nthawi yoposa masiku a 21 pakati pa mapeto a nthawi imodzi ndi kuyamba kwa lotsatira.Ofufuzawo adayesa kusintha kwa kulemera kwa thupi, BMI, kuthamanga kwa magazi, ma testosterone, miyeso ya zochitika zatsopano za mtima, ndi zoopsa zomwe zimachokera ku miyezi ya 3 isanayambe jekeseni yoyamba mpaka miyezi 12 chiyambireni chithandizo.
Gulu lophunziralo linali ndi amuna a 948 omwe amatenga testosterone undecanoate ndi amuna a 121,852 omwe amatenga testosterone cypionate.Pachiyambi, 18.9% ya amuna mu gulu la testosterone undecanoate ndi 41.2% ya amuna omwe ali mu gulu la testosterone cypionate analibe matenda a hypogonadism.Kutanthawuza testosterone yaulere pachiyambi inali yapamwamba kwa odwala omwe amatenga testosterone undecanoate poyerekeza ndi omwe amatenga testosterone cypionate (65.2 pg/mL vs 38.8 pg/mL; P <0.001).
M'miyezi yoyamba ya 6, chiwerengero chotsatira chinali chofanana m'magulu onse awiri.Kwa nthawi ya 7 kwa miyezi 12, gulu la testosterone undecanoate linali ndi chiwerengero chapamwamba chotsatira kuposa gulu la testosterone cypionate (82% vs 40.8%; P <0.001).Poyerekeza ndi miyezi ya 12, chiwerengero chachikulu cha amuna mu gulu la testosterone undecanoate chinapitirizabe mankhwala a testosterone (41.9% vs 0.89.9%; P <0.001).Amuna omwe amatenga testosterone cypionate.
"Chodabwitsa n'chakuti, 8.2 peresenti yokha ya amuna omwe adabaya testosterone cypionate anapitirizabe kulandira chithandizo pambuyo pa chaka cha 1," adatero Morgenthaler."Kutsika kwambiri kwa mankhwala a testosterone omwe amagwiritsidwa ntchito kwambiri ku United States kumatanthauza kuti amuna omwe alibe testosterone amapatsidwa chithandizo chochepa."
Odwala omwe amathandizidwa ndi testosterone undecanoate anali ndi kusintha kwakukulu kwa testosterone (171.7 ng/dl vs 59.6 ng/dl; P <0.001) ndi testosterone yaulere (25.4 pg/ml vs 3.7 pg/ml; P = 0.001).Kuwonjezeka kwa miyezi 12 poyerekeza ndi odwala omwe amathandizidwa ndi testosterone cypionate.Testosterone undecanoate inasonyeza kusiyana kochepa m'magulu onse a testosterone kuposa testosterone cypionate.
Pa miyezi 12, kusintha kwakukulu kwa kulemera, BMI, ndi kuthamanga kwa magazi zinali zofanana pakati pa magulu.Gulu la testosterone undecanoate linali ndi chiwerengero chapamwamba cha amuna omwe anali ndi vuto la erectile ndi kunenepa kwambiri potsatira, pamene gulu la testosterone cypionate linali ndi chiwerengero chapamwamba cha amuna omwe anapezeka ndi matenda oopsa kwambiri, kulephera kwa mtima, ndi kupweteka kosalekeza.
Kafukufuku wochulukirapo akufunika kuti amvetsetse chifukwa chake amuna ambiri omwe amabaya testosterone cypionate amasiya chithandizo mkati mwa chaka, Morgenthaler akuti.
"Titha kuganiza kuti mu phunziro ili, testosterone undecanoate idagwiritsidwa ntchito mochuluka kwambiri kwa miyezi ya 12 chifukwa cha kuphweka kwa mankhwala omwe akhalapo kwa nthawi yaitali, koma kuti awone ngati izi zikhoza kukhala chifukwa cha zifukwa zina (monga mtengo), kutsutsa jakisoni wodzipangira pafupipafupi, kusowa kwabwino kwazizindikiro, kapena zifukwa zina," adatero Morgenthaler.
Nthawi yotumiza: Jul-05-2023